Researchers found that one mechanism by which antibiotics induce drug-resistance mutations in bacteria is by triggering the generation of high levels of toxic molecules called reactive oxygen species (ROS). Additionally, treatment with a ROS-reducing drug approved by the US Food and Drug Administration for other purposes prevented these antibiotic-induced mutations.
Anti-evolvability drugs could slow antibiotic resistance in bacteria
Science Daily - 1 Apr 2019 17:58
Researchers found that one mechanism by which antibiotics induce drug-resistance mutations in bacteria is by triggering the generation of high levels of toxic molecules called reactive oxygen species (ROS). Additionally, treatment with a ROS-reducing drug approved by the US Food and Drug Administration for other purposes prevented these antibiotic-induced mutations.
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